So far, many variants of the Novel Corona virus, which first appeared in the year 2019, have been detected, in which people have to face many types of health problems. Some variants were found to be highly contagious, while others caused severe disease in people. Scientists have noticed a major change in the nature of the virus for some time now. Experts found that Omicron’s sub-variants, the variants resulting from the combination of two viruses and the XE variant, believed to be the most infectious of the recently discovered corona, could dodge tests.

Researchers on Kovid-19 cases say that each variant has a different genomic structure, based on which it can be known which part of the body the virus can affect more and what kind of symptoms as a result. Are there any doubts? But the nature of many of the variants that have appeared since Delta has been observed, which helps it to dodge RT-PCR tests. Let us know how the infection can be detected in this situation? Also in which variants such nature is observed?

Confirmation of infection by RT-PCR test

Health experts say that since the beginning of the epidemic, real-time RT-PCR test is being considered as the gold standard for confirmation of corona virus infection. For this test, a swab sample is taken from the nose and mouth, on the basis of which the infection is confirmed. This test has been considered to have accurate results to understand the severity of the condition and to know the viral load. However, the nature of some variants is such that they are not detected by this test, in which case a genome sequencing test is needed.

What is Genome Sequencing Test?

It is easy to know the nature of the entire DNA of the virus through the genome sequencing test. Genome sequencing tests are considered helpful in understanding what changes are in the spike protein of the virus and what kind of problems can be caused by it. Genome sequencing test is also considered helpful in understanding how much has changed from the origin of the virus to its mutant version. That is why this test has been done to detect Omicron.

New variants being saved from RT-PCR test

In a number of recent studies, researchers have reported that the spike protein of the new mutant variants does not contain certain components that are required for detection in RT-PCR tests. Apart from this, many changes are being seen in the nature and characteristics of the new variants. Initially, where corona was known as a respiratory infection, now its effects are being seen on other parts of the body as well. Some people are only having stomach related problems, so it becomes difficult to detect the infection through nasal swab.

New variants are dodging RT-PCR test

The UK Health Services Agency (UKHSA) said in a study conducted on Omicron BA.2 that it does not contain a mutation that helps in the detection of Kovid-19. A genetic deletion was observed in Omicron’s ‘S’ spike gene that would have made it easier to confirm infection with RT-PCR testing, although the ba.2 sub-variant does not have that S gene, because It can be difficult to track.


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